For sure! I've just found alacrity has felt great since the 11.2 buffs, and they can be decently easy to get- especially if you send a nice ult to a team fight across the map- tbh Ive only played a about a dozen games with it, so still tweaking the runes! Coup de grace is the only other alternative I think (+ POM)

I could definitely see biscuits + approach velocity being good- i know her passive steals a bit of ms but does that apply AV? Other than your W it wouldnt really kick in until Frostfire but could still work?

Manaflow+ transcendence? CDR would be really nice, especially late game.. idk manaflow is essentially POM, that extra attack speed allows her to do what she does best, auto attack to refresh Q and get stacks.

I dont really see domination tree being worth it over the others tho- as you'll almost inevitably need a tear early on