If you practice your draw with the safety engaged, then you would not be wasting 'seconds' in disengaging it. Even chambering a round would take far less than a full second, if practiced.

The bottom line is that I'm not bothered about chambering a round for the types of situations that I anticipate occurring at my workplace. The risk is too high for the sort of holster that I have, combined with the sort of work that I do. The holster is fabric, not a hard-shell. I can imagine (very simply) myself leaning over a milk-crate while sucking-in my gut, with the corner of the milk-crate piercing into my abdomen, while I move downward to reach for another object. This sort of action happens frequently. I'm not going to risk a discharge 20.. 40 times each day - however low may be the probability of a discharge actually occurring.

I've seen the videos, and read the arguments. And I still feel that I'm best-off keeping my LCP II unchambered in this sort of circumstance. I certainly feel less secure than I do when I have a chambered handgun, but it's an insecurity that I feel that I need to accept.

(and, as I meant to imply with the 'spilling drinks' and 'pissing myself' section - I drink a lot of alcohol. I'm safe with my guns, but the manual safety gives me the extra confidence that means I don't have to be constantly fearful of a drunken, negligent-discharge.)