4-ACo-DMT trip and vasoconstriction

Also not true, lol. (well yes if you do have extreme vasoconstriction ie ergot poisoning you can't masturbate)

The dopamine receptors in the brain (speed and MDMA are strong agonists of dopamine) distract from the ability to have sex. Also, serotonin plays a huge role in sex (and erections), and psychedelics and MDMA affect those receptors in the brain.

I never found LSD or psilocybin to be aphrodisiac, but mescaline was. It has nothing to do with vasoconstriction.

All these drugs affect these receptors differently. It has nothing to do with vasoconstriction.

I suggest you read this to get an idea of how serotonin plays a role in the ability to get an erection.

Using Viagra with MDMA to facilitate erections in Males Jan. 18, 2004

I have seen many references to mixing MDMA and Viagra, and many warnings accompanying them. Unfortunately, most of the warnings that I have seen seem to be parroting what someone else has "heard" as opposed to referencing any concrete scientific data.

This is a mix that I have used on several occasions without any ill effects. But it is not something that someone should do casually. These two drugs can be taken safely together as long as one understands the medical issues that must be taken into account. In saying that, I would like to point out that I am NOT a medical doctor. And I strongly recommend that anyone thinking about mixing MDMA and Viagra first read scientifically authoritative research material available and draw their own conclusions. I would also recommend, if possible, that you speak with your doctor first and make him or her aware of your intention to start using Viagra.

Viagra (Sildenafil citrate) started out as a drug product designed to reduce blood pressure. It is a vaso-dilator, meaning that it expands (relaxes) blood vessels. It is unique in that its vaso-dilator properties have the side effect of producing erections in men. Viagra does NOT produce sexual stimulation, and anyone who claims that it makes them "horny" is simply responding to a placebo effect (i.e., it can produce erections independent of sexual stimulation).

Women should not take Viagra. There does not seem to be a positive sexual benefit from Viagra for women. At least, a woman should first speak to her doctor before attempting to take Viagra. (Currently there are other drugs under study for use by women for increased sexual function. Your doctor can provide more information about such drug studies and availability.)

MDMA tends to prevent erection in a percentage of males. I do not know what the exact percentages are (there is no statistical data available for this that I am aware of). However, from the reports that I have read, it appears that erectile inhibition is experienced by the majority of males while taking MDMA. I have a feeling that this occurs as a result of MDMA's interaction with the serotonin receptors, and specifically with the 5HT1a, 5-HT1b, 5-HT1c and 5-HT2 receptor sites (5HT1a has specifically been suggested as the reason why patients taking SSRI anti-depressants experience erectile inhibition). I do not have any hard scientific data to back this up with respect to MDMA (again, I don't think that any studies of this kind exists), it is just a guess on my part.

Something else of note, with respect to the 5HT1a serotonin receptor, is that it is also involved in the ejaculation response. Inhibition of this receptor can result in delayed ejaculation (which, again, occurs in some male patients taking SSRIs).

Why does Viagra produce erections in males also taking MDMA? It appears that MDMA disables the erection mechanism by turning off the "switches" in the brain which are required to produce erections. Viagra bypasses this mechanism by directly producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood into the penis (see: Viagra Drug Pharmacology). This is effectively what the brain does during sexual excitation, except Viagra performs this action independently of any brain activity being incorporated.

Ejaculation / Orgasm

During the MDMA Experince It should be noted that, although Viagra can produce erections in males taking MDMA, it will NOT aid in achieving an ejaculation / orgasm. In fact, this mix tends to produce a condition where sexual stimulation is possible, erection is possible, but ejaculation can not occur. Depending on your goals this can be either a positive effect or a negative one. On the one hand, this mix makes it possible for a male to have uninterrupted sexual intercourse for a very long period of time. On the other hand, orgasm is not possible until after the full effects of the MDMA have subsided (i.e., when the specific 5HT receptors are "freed up" to allow for the normal brain/erection/ejaculation process to occur).

So, if one desires long periods of sexual activity then this is an ideal combination. Or, if one wishes to achieve an orgasm, this can be a very frustrating mix.

Possible Post MDMA Side Effect An interesting side effect that I have noticed is that delayed ejaculation can continue for a day or two after an MDMA experience. It is by no means as pronounced as during the MDMA experience itself. But there appears to be additional "staying power" during sex than normal. I suspect that this has something to do with the 5HT receptors "reorienting" themselves after the MDMA experience has concluded, and that this process requires several days for the receptors to return to baseline. I have absolutely no idea what percentage of males experience this post-rolling effect.

Health and Safety Issues

Determining the Correct Dosage There is nothing "safe" about popping an E with a Viagra. Doing so "casually" is pretty stupid. For one thing it has been surmised that both Viagra and MDMA utilize the same metabolising enzyme P450-3A4 (see: Ecstasy and Viagra - Ecstasy.org). And this may result in a larger amount of Viagra being utilized then when no MDMA is present. As a result, it is important to take less Viagra then would normally be required.

The correct way to determine the your dosage of Viagra is to use small amounts during multiple MDMA experiences, and increase the dose slowly for each experience until the correct amount for your system is attained. Once you have found the right dosage to produce an erection DO NOT increase the dose beyond that point.

Let me say this again: 1) TAKE MDMA + A SMALL DOSE OF VIAGRA. 2) DO NOT INCREASE YOUR VIAGRA DOSE ANY FURTHER FOR THIS ROLL. 3) MARK DOWN THE VIAGRA DOSAGE AND TRY A SLIGHTLY LARGER VIAGRA DOSE THE NEXT TIME THAT YOU ROLL. 4) ONCE YOU HAVE BEEN ABLE TO ACHIEVE A SATISFACTORY ERECTION DO NOT INCREASE THE DOSE OF VIAGRA ANY FURTHER. 5) AT THAT POINT YOU HAVE FOUND YOUR MAGIC DOSAGE.

Becoming familiar with Viagra's Effects It is probably wise to first try taking Viagra separately before attempting to incorporate it into the MDMA experience. This will allow you to better understand how Viagra effects your body, and give you a better idea of what to expect when mixing it with MDMA. Remember that Viagra is primarily a blood pressure medication, so you will notice that you fell somewhat different under its effects.

Dose Management

Dose increments Ultimately, the dosage which you will require for your body is largely dependent on your health and your age. It is best to initially start off with a dose of around 10 to 25 mgs. of Viagra, and then add an additional 10 to 25 mgs. for each roll until you have found your ideal dosage.

Viagra is available in both 50 and 100 mg. tablets. Because of this, to obtain a smaller dose increment it is necessary to divide tablets into smaller parts. This can be done with a pill splitter, a razor blade, or even a sharp knife. When using a razor blade or knife, be especially careful not to cut yourself.

Stagger your doses Do not take the MDMA and Viagra at exactly the same time. Take the Viagra first, wait 30 minutes and then take the MDMA. If you take both drugs at the same time you may experience a light headnesses, or feel that your heart is beginning to race. This is a temporary effect and it will pass in under one half hour. Just sit down and relax.

Under some situations, it may not be convenient to take the Viagra first, and you may want to wait until later on after you have taken your first dose of MDMA. This is alright. but remember that it can take a while for the Viagra to work (anywhere from 45 minutes to an hour or so). The important thing is not which drug you take first, but rather, taking them in different time frames. This allows your system to metabilize them separately, and reduces any uncomfortable side effects.

/r/Drugs Thread