There are NAH. Aside from the personality differences, your wife wants you to do something that she isn’t willing to do on behalf of a member of your family. You can tell her that you support her going to visit for an extended period of time if she needs to help care for her mum, but that a permanent relocation isn’t in the cards for you.

You don’t say whether there are children involved or what your ages are, but you should be prepared for your marriage to end over this. I’m not making any value judgements over whether it’s wrong or right for your wife to ask you to move when she indicates she’s unwilling to do so, but she may choose her family over you.