Don't take too many you'll have a seizure. Don't take them with any other serotonin effecting drug. Because they do mess with your serotonin unlike most other opiates. And you'll fall into serotonin syndrome which is fatal in some cases. No take them on empty stomach. Need food with these as it not only prevents nausea but helps their absorption rate. Take them every 15 or 20 or even 30 minutes not all at once as it will help their absorption. All this being said you can literally just pop em though no prep needed or anything and still get high its just these are tips but do keep in mind their seizure threshold especially if you already have a low seizure threshold. Message me if you got further questions.