Note the average person thinks they are more resistant to advertisement than most people. Many people think the goal of an ad is to persuade a person to buy into the good / service advertised. While that is true, it is only a small part of the methods. What I mean by that is ads push more to be memorable so that the target audience actively know the product/service's existence. When the time comes for a consumer to want/need a service/product they can only choose from selections they actively know (unless they research).

Ads do work on Sci-Fi goers. However, the situation is more about whether or not Sci-Fi goers are the target market. You may be right to say that NFL fans would be the better target demographic for beer than Sci-Fi fans. But another product/service might cater better for Sci-Fi goers. Like... I don't know. Something with spaceships? You may be onto something since now that I think about it Sci-Fi goers tend to be part of the demographic that is internet savvy. That is in using ad-block and prefer uninterrupted streaming.

Since targeted ads are a thing now. I went to see what ads I got on youtube: beer commercials, car commercials, laptop commercials, online casino commercials, online broker, team management product, grammar correction app... Seems about right. But where are my spaceship ads? D;