Assuming one's on TRT, at what age would you no longer be able to gain muscle? Asking generally (obviously it would vary by individual).

I’m not even going to bother with your comment about olympic weightlifters, because olympic weightlifters don’t bench. Gaining muscle and getting stronger are indeed two different processes, but the strongest correlate for muscle strength is that muscle’s cross-sectional area (ie how large the muscle is.)

The aging process will slow down muscle gain, but it does not stop. For further reference, see below:

“Likewise, progressive resistive training in older individuals results in muscle hypertrophy and increased strength, if the training stimulus is of a sufficient intensity and duration. Since older individuals adapt to resistive and endurance exercise training in a similar fashion to young people, the decline in the muscle's metabolic and force-producing capacity can no longer be considered as an inevitable consequence of the aging process.”

Source: https://pubmed.ncbi.nlm.nih.gov/8504850/

“Among individuals aged 50 and older in the US, muscle mass and muscle strength are positively correlated, independent of the associations of age and gender with muscle mass and strength. A variety of comorbid medical conditions serve as independent predictors of lower muscle strength (e.g., diabetes, CHD/CHF, vision problems) and/or modify the relationship between muscle mass and muscle strength (e.g., obesity).”

Source: https://bmcgeriatr.biomedcentral.com/articles/10.1186/1471-2318-13-74

“RE is effective for eliciting gains in LBM among aging adults, particularly with higher-volume programs. Findings suggest that RE participation earlier in life may provide superior effectiveness.”

Source: https://pubmed.ncbi.nlm.nih.gov/20543750/

“Twenty-one trials (n = 973 participants) were included. Exercise significantly improved morphological MQ (effect size (ES) = 0.32, 95% CI 0.13–0.51, P < 0.001) with significant results maintained for studies assessing muscle density and intermuscular adipose tissue (ES = 0.45–0.52, P < 0.05).”

Source: https://www.nature.com/articles/s41598-021-00600-3

“The meta-analysis showed that power training was superior for muscle hypertrophy compared with control condition (n = 8 studies; standardised mean difference (SMD) = 0.31; 95% confidence interval (CI) = 0.04, 0.58; p = 0.029), and resulted in similar hypertrophy compared with moderate-velocity resistance training (n = 7 studies; SMD = 0.07; 95% CI = –0.18, 0.32; p = 0.50). No significant heterogeneity was observed (p = 0.46 and 0.54, and I2 = 0% and 0%, respectively). Our data suggest that power training is effective for muscle hypertrophy in older adults, with similar effectiveness as moderate-velocity resistance training. “

Source: https://cdnsciencepub.com/doi/10.1139/apnm-2020-0021

“In older adults, skeletal muscle tissue is still capable of inducing SC proliferation and differentiation, resulting in Type II muscle fiber hypertrophy.”

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655000/

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