Two weeks old not really gamed till last night, fired Witcher 3 and was literally confronted by a banshee wailing at me. Tested two different PSUs A EVGA Supanova G2 1000w and a old Silverstone OP1000 I had in the cupboard. In this example I don't actually load a game I managed to replicate the issue by playing a high quality video using madvr with very high settings & CUDA hardware decoding enabled. Its very distracting especially as my rig sits to the right of me on my desk, also while actually gaming last night with all the fans on its could be easily heard above them and was much louder and more like a high pitch wail which fluctuated in volume and pitch.

Specs: Asus ROG Crosshair VI Hero Strix Geforce GTX 1080ti EVGA Supernova 1000 G2 F4-3200-16GTZR