Is this just adulthood? Is this crippling depression?

Nah it's just media, and there's plenty of it to choose from. You will never be able to consume all the "greatest works" of media before you die, let alone all great works, let alone all the things you might happen to enjoy. So don't worry about trying to like something you don't like.

Maybe you just don't like anime anymore, but now your brain will release dopamine while watching all 413 seasons of NCIS or some shit, who knows?

Now if you're having trouble getting interested in anything? That's the crippling depression. In which case I feel ya brother lmao keep on truckin' big oof etc.