Chem stacking strategies?

To my knowledge if the drug effect is identical, it won't stack. Overdrive does not stack with Psycho's damage buff or any of it's variants. While in your effects tab it will show these buffs as separate, looking at your gun damage after applying each one will make it apparent to you.

Another drug worth looking into is Fire Belly. If you operate at about 70%~ radiation (For Inquisitor of Atom/Easier Procing of Destroyer of Arcadia and Nerd Rage) you can get a decent damage bonus from it as well.

Generally speaking, you don't want to take drugs for the +25 DR, as it's minorly helpful at best. Same is true for AP. Heavily suggest carrying around quantum for very rare situations or just forgoing it as a concern.

Generally I walk around with Overdrive and Orange Mentats permanently on gun builds, due to how easy they are to craft, and have Firebelly for emergencies (Read as: Never) Jet variants always tend to be either a pain to craft, or just ineffective. I don't use slowtime so I can go into VATS, so why does Ultrajet give me AP? And only for a few seconds?

/r/fo4 Thread