Inspired by /u/ Jakkubus's old comment.
This pair together should be able to most or all of the opposing team.
Index franchise Thor has his Almightly spell, which protects him from harm and facilitates his attacks by shifting the world (and people) in relation to himself.
Even if they figure out the spell's mechanics, the in character S-tiers wouldn't take the necessary step of destroying the world to neutralize Thor. Taking the fight away from Earth is a possible solution, but once again they would need to figure out it's mechanics to arrive at such a solution.
Nonessential characters that can form deadly combinations of their own if somehow Index!Thor & Shiki fail.
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