3. Crystal structure of SARS-CoV-2 main protease provides a basis for design of imp...

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors - Given these favorable pharmacokinetic results, our study provides a useful framework for development of the pyridone-containing inhibitors toward anticoronaviral drugs.

I've been studying biochemistry for the past 5 years so i'm a bit of a weirdo and also a nerd when it comes to this stuff. I also do research in a computational structural biology lab, where we simulate protein movement using computers. So i'll try to break this down a bit more: as stated by the person above me, in proteins structure dictates function. The function of the protease is to cut the protein chain produced by the virus that then becomes machinery which hijacks the cell and uses it to make more virus. If that function is blocked, the protein chain parts cannot fold into a functional 3D conformation because it does not have the right length or sequence. Hopefully that clarifies things a bit further.

/r/science Thread Parent Link - science.sciencemag.org
Previous
Next

Recently removed from /r/science

As a four-day work week is trialed in countries across the globe, health researchers say they’re ‘all in’ when it comes to a long weekend, research shows that the extra time off is good for our health. Findings from a study of more than 46,000 people from 68 different countries reveal those who share more left-wing political views are more generous and altruistic than those who follow right-wing ideologies. Obesity might adversely affect social and emotional development of children, study finds Decline in daily step count persists after pandemic for U.S. adults. Based on new findings, people had not yet bounced back as of December 2021: U.S. adults were still taking around 700 fewer steps per day, compared to their pre-pandemic norm. Review of 1,039 studies indicates exercise can be more effective than counselling or medication for depression Researchers are calling for exercise to be a mainstay approach for managing depression as a new study shows that physical activity is 1.5 times more effective than counselling or the leading medications One theory of attractiveness suggests beautiful people are seen positively and these views become internalized, motivating altruistic behavior. New research, however, finds support for the view that beautiful people behave selfishly and feel entitled due to their bargaining power in relationships. Extremely rich people are not extremely smart. Study in Sweden finds income is related to intelligence up to about the 90th percentile in income. Above that level, differences in income are not related to cognitive ability. ACPeds Calls on Organizations to Scrap Current Transgender Protocols Based on Newly Published Critique Most Americans aren’t getting enough exercise. People living in rural areas were even less likely to get enough exercise: Only 16% of people outside cities met benchmarks for aerobic and muscle-strengthening activities, compared with 28% in large metropolitan cities areas. Magnetic solution removes toxic "forever chemicals" from water in seconds Neighborhoods with predominantly White residents have more greenery, fewer dilapidated buildings and fewer multi-family homes — compared to neighborhoods with residents of multiple races and ethnicities, predominantly Black residents Routine vaccinations drop among U.S. kindergartners for the third year in a row according to the CDC. While vaccinations remain high, coverage has dropped from 95% in the 2019-2020 school year to 94% in 2020-2021 to 93% in 2021-2022, leaving at least 250,000 potentially unprotected against measles. Clitoral knowledge and gendered sexual scripts appear to play a key role in women's orgasm experience Clitoral knowledge and gendered sexual scripts appear to play a key role in women's orgasm experience

More Random Comments

Was ist der größte Abturn des anderen Geschlechts? Jesus, real or not? Vegetable snack ideas Asian students under attack, again, by DOE How hard is this game at max level with max stats? Aw man, just when it was getting good So the advice goes don't talk to the police without a lawyer. What would the conversation typically be like if you talk to the police with a lawyer? Lots of "don't answer that"? What does a lawyer bring to the table? Making up rules on the spot, are we? The evolution of our face, which took longer than 450 million years. The Introduction Cutscene is a lie! (The Truth of this World - Part I) Tim Barrier to first generation students. Question David Schwimmer, Sarah Silverman and More Condemn Antisemitism in David Baddiel’s Documentary ‘Jews Don’t Count’ I don't believe the "new ira" is responsible for the strabane fiasco. It reeks of uvf.