I'm used to using right handed guns in real life (bolts are always a fun puzzle) considering how only a few modern semi-auto pistols are ambi/swappable. I'm fine with adjusting how I cock/decock/eject etc. for a right handed gun. An AK for example you just reach under/over while tilting which I actually find more beneficial. The main thing is just the movement and turn sticks, I always use direct locomotion (no teleport) so when they swap the sticks it's like someone asking you to walk somewhere on your hands, or in a mirror.

"left handed" to me would mean providing the option to swap if they really want it but most importantly swap holster/shoulder locations and maybe button mappings if they're related to the weapon (eject mag etc. should be on main hand)