ELI5:Why does the body build a tolerance to some substances but not others?

I've had a theory (one of my many) that a part of my "depression" is physical pain. When people feel my back, even sports massage therapists, they're always astounded. I have knots from my traps to my lower back, in my chest, even small ones on the muscles over my rib cage, basically every muscle group you can think of has knots. I've gone through phases where I stretched rigorously and honestly it's futile, though I'm sure it only helps. I also believe I have at least one hernia (inguinal) that I feel in my groin just over left testicle, which may or may not be responsible for a pain that extends from my left hip to upper glute/lower back. I have shoulder problems that may be part of the knots or separate (torn labrum or something). But the weirdest part about this is it's almost never on my mind. I get flare ups here and there but unless something cues my attention to it I really don't consciously experience it. Yet anyone observing my day to day behavior would think I'm severely depressed. I feel a whole lot of nothingness to the point where I've made these systems where I replay events in my head and crank up the "volume" to sort of hammer in the emotional value of the situation. I have no motivation to even get the hernia thing checked out. I try not to connect everything into one thing... as in I think of my pain issue as separate (or not a major factor) from my psychological/emotional stuff. IDK but that's interesting.

/r/explainlikeimfive Thread Parent