strat for attempting to full clear:
floors 1 & 2, focus on getting coins, spending coins at the merchant, getting boons, and doing the pacts.
avoid the following afflictions: reduced movement speed, 30% increased action speed for monsters/monsters cannot be slowed below base, you are not always taken to the room you select, hidden afflictions
every room type on each floor is the same layout. for "find the exit" maps, you can usually get out (especially on floor 2 & 3) in <3 seconds if you remember the layout
inspiration goes to 1000. it's awesome. use it/get it where you can
best relics imo: anything with gain resolve when you click a fountain, %inc maximum resolve, see additional rooms, inspiration when you get an affliction
also, make sure you go to the fellshrine ruins in both act 2 and act 7 to get all the quest crap you need