I grew up in Vancouver (but no longer live there). It’s hard to say definitely, as it’s a bit of a mixed bag: there are definitely aspects of Seattle and Portland that resonate with Vancouverites, a shared culture and outlook in some respects, sort of a familiarity in outlook and lifestyle.

On the other hand, there are cultural weirdnesses about all Americans that make Seattle and Portland a bit unfamiliar and seemingly less culturally close than other Canadian cities, even those far away. Standard differences like attitudes to social programs, healthcare, sports, gun ownership, metric system, etc. and even some linguistic differences that don’t exist between Vancouverites and other Canadians.