Are we just going to completely ignore the fact the article linked suggests that the primary reason for the dislikes is sexism? It's not that the cast is women, it's that the original cast did not return.

There is a lot of hatred directed towards the new trailer, primarily because it stars four women (though the haters would have you believe misogyny is not the real driving force behind their invective) and seemingly not at all connected to its quality. Quickly the misogyny began to overwhelm the comments under the Ghostbusters trailer and Sony Pictures was forced to delete many offensive remarks, though it doesn’t take long even now to find comments like, “When are people going to learn that women aren’t funny?“ and “GhostBusters – Fat Dyke Edition”. The dislikes eventually got to a point where it became a game among those who hate the movie and frequently return to watch the numbers grow. When one fan commented, “We made it to 500000 dislikes,” another followed up with an enthusiastic, “Lets [sic] get it to a million!”

And that’s really the bigger problem here. It’s not that people disliked the movie on an organic level. As shown above with Fantastic Four and Ridiculous Six, even when people don’t like a movie they don’t “dislike” it this much. The thumbs down votes aren’t organic, they’re part of a coordinated attack on the film by people who are opposed to its very existence. There have even been reports across the web that angry fans are using bots to artificially drive up the “dislikes” on the trailer. What’s worse, there’s a culture of misogyny and toxicity to YouTube comments that fosters this type of attitude. Just a quick look at the same trailer posted by Sony Pictures to Facebook shows only 12,000 “angry” votes (the Facebook version of the thumbs down “dislike”) on 22 million views.