A bit of a tangent note, but in my personal opinion:

The prime directive is seriously cruel!

It's like you're standing there watching an alien civilization and saying,

"You know, I see hundreds of millions of you dying from a plague--a plague that you'll clearly be able to cure in a couple of decades, a cure I could also hand to you right now. But naaah... good luck with a few decades of misery and suffering!"

Some people argue back, and say, "Ya but, it will make their species stronger in the end, and weed out the weaker ones."

At which point I usually ask:

"Have you or someone you love ever taken antibiotics? Gotten vaccines? Had a life saving operation? If so, given your philosophy you should decline all those things next time, and just... you know: let nature take its course with your body!"

In the end...

It's not like any of us in this discussion invented antibiotics or life saving technologies, nor would even know where to begin to re-invent the micro-computer revolution. Yet we still use and profit greatly from these technologies.

Most of us don't think twice about using such technologies when needed and offered, even though we individually know virtually nothing about the seeming magic of the technology itself.