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Studies with positive results
Study 1 – March 16, 2020Researchers from China reported in a letter that over 100 people with COVID-19 have been treated with chloroquine. These patients had less severe ....
Study 2 – March 20, 2020 (peer-reviewed but under further investigation**)**A small study in France reported that people who got 600 mg of hydroxychloroquine had a lower amount of the virus (viral load) in the body. The problem with this study is that comparisons were made betw....
Six people in this study also received azithromycin (a common antibiotic) with hydroxychloroquine. These individuals had even lower viral loads at the end of the study compared to those who only got hydroxychloroquine. This research group later released another article looking more into hydroxychloroquine and azithromycin in a study of 80 people (including the 6 above). They ...
More information on safety is also important because taking azithromycin and hydroxychloroquine together can increase the risk of serious side effects, particularly irregular heart rhythm.
Study 3 – March 31, 2020A small, randomized study of 62 people in Wuhan, China looked at how well hydroxychloroquine worked for hospitalized patients with mild COVID-19. C..
Studies with negative results
Study 4 – March 24, 2020In a small Shanghai study of 30 people with COVID-19, half got 400 mg of hydroxychloroquine for 5 days while the other half did not. At the end of t...
Study 5 – March 30, 2020Another small study in France wanted to verify the results of Study 2 above, so they gave 11 people the same combination of hydroxychloroquine..
Study 6 – April 14, 2020In a study of patients hospitalized with COVID-19, 150 people were randomly assigned to either receive high doses of hydroxychloro..
Study 7 – April 21, 2020A retrospective study looked at veterans affairs (VA) hospitals across the U.S. and identified 368 male veterans who were hospitalized wit...
**Study 8 – May 7, 2020 (New England Journal of Medicine)**In a large observational study of 1,376 hospitalized patients with COVID-19 in New York City, 811 people (59%) received hydroxychloroquine. There was minimal difference in the risk of needing a breat...
**Study 9 – May 11, 2020 (Journal of the American Medical Association)**Another large observational study of 1,438 hospitalized patients with COVID-19 in New York state also did not see a difference in death rates between thos...
**Studies 10 and 11 – May 14, 2020 (British Medical Journal)**Two unrelated studies, both published in the British Medical Journal (BMJ), concluded that hydroxychloroquine was not helpful in treating hospitalized patients with COVID-19. The first was a retrospective study done in France that looked at 181 patients who required oxygen in the hospital but were not in the ICU (intensive care uni...
The second study was completed in China. One hundred fifty hospitalized patients were randomly assigned to either get hydroxychloroquine or n...dication, which can make the results a bit tricky to interpret.
**Study 12 – May 22, 2020 (The Lancet)**A large study31180-6/fulltext) looked at a database of 96,032 hospitalized patients with COVID-19 across 671 hospitals and 6 countries. About 15,000 of the patients got hydroxychloroquine or chloroquine with or without an antib...