Work at a tertiary care center. Over the past few years we’ve had an explosion of these cases in young, white women who self-proclaim themselves as “medical mysteries” and claim they can’t eat, exhibit significant anxiety, high ACE scores, hx eating disorders, etc. We had to close our genetics clinic to EDS evaluations and no longer evaluate hypermobile pts unless +findings for/family hx suggesting pathology like marfans, vascular EDS, or loeys-dietz. Patients with either borderline or self-dx often refuse psychiatric evaluation and can be massive time, resource, and empathy blackholes. How do we appropriately manage these cases when there are no findings suggesting organic pathophysiology?