You cannot compare.
There are, however, reasons to argue the PL is more demanding, and that is down to our scheduling. That is also why our national team, allegedly, falls short of expectations.
Not that we should be winning, we're actually punching above our weight in terms of population size with regards to the size of our talent pool.
I don't believe that Barca, Bayern, PSG, Real, Atletico, Dortmund, Juventus, etc etc would walk the fixtures. The compound effect it has, and the physicality is very demanding. A few teams would be able to handle that regularly from overseas. But would inevitably fall short with injuries and fatigue. Not to mention the way games are officiated.
I'm not saying we're special, but we are different. In the same sense that if most PL teams regularly played in Germany, Spain, Italy we would struggle with such things as...
There are a handful of teams that I think could adapt quickly. The key one that stands out is Atletico. Strong players, disciplined.