Seconded. I know it was an off-the cuff comment, but I'm male and infertile. I can honestly say that 6 years after I found out, not a day goes by that I don't have some thought about it. Not to say I'm depressed or sad about it every day, but something small every day reminds me that I can't have that.

My wife and I are actually going through IVF right now, and there's a tiny chance that our (incredibly expensive) doctors can make a miracle happen and give us children that are biologically mine (long story there, I was ready to use a donor, she wanted to exhaust our options). Even now, every shot she has to take, the soreness she's feeling from the procedures, I don't physically feel it, but I feel responsible, and horrible, for every bit of it. The worst her friends had to go through to get pregnant was having to have sex with their husbands more frequently than normal. She has to suffer through uncounted shots and procedures, not to mention the financial sacrifice, and the rollercoaster of hopes and disappointments that this process brings.