depends on the person, sometimes SSRI’s minimize or cancel out the effects of psilocybin/lsd. but it worked just fine for me when i was on zoloft and my friend who also takes several diff medications including SSRI’s. be careful though, you can start off with microdosing to gauge where you’d want to be at. if i’m going to take any substance that creates visual effects i’d take either one. i’d rather see pretty colors than the notorious hat man on DPH. it’s also so hard to abuse, it just truly isn’t addictive. there are some studies showing that shrooms can actually create new neural pathways in the brain. but everyone’s different, i have known people that tripped every week which is not good. everything in moderation is key. please stop frying your brain with DPH.