The first time I did any drug it was mushrooms at about age 17, I am now nearly 40. I'd only even had alcohol... maybe a couple beers once I think. I drastically and completely changed my personality for the better from that one experience.
It wasn't like I was sitting there having this crazy 3 hour revelation either that blew my mind.
I was always a very angry teen, and although I appeared calm and wacky go lucky on the outside, extreeemely internally violent.
In the middle of that experience I thought to myself, boy I'm sure angry a lot... it takes a lot of effort to be angry. I'm never going to be angry again.
...and I never was. Really over anything. Loudly disappointed to the point of being overwhelmed a few extreme times sure, but none of that heat/fire. It was just gone forever. That's all it took. Two sentences in my head that stuck with me and made me a better person forever.