Prob should be on r/askdrugnerds or r/stackadvice though it’s a bit advanced for the latter and a bit too simple for the former so ill answer it here.

In class atm so only had time to review one of the studies (the first), it suggests that the MoA of an anti-immobility effect in mice hung from their tails is partially due to an inhibition of NMDA receptor activity.

Overall creatine likely isn’t a very potent nmdar antagonist, but I have heard of some people using it ^AS PART of a method of limiting glutamate excitotoxicity. If you are looking into nmda antagonism for means of tolerance reduction/prevention to certain drugs or for anti-depressant effects, creatine would likely help with both, but through increased capacity for intense exercise more than the nmda effects, though they would likely help as well. Agmatine sulfate would help with both exercise performance and is a stronger nmda antagonist from what I know, Agmatine has several other effects and you should research it further or consult a physician before supplementation with it etc.

Hope this helps.