-Tools/supertools and stat ups are very valuable in the game, make sure you have some sort of plan to utilize them properly.
-There's nothing "technically" missable due to the very high replayability of the game.
-You'll come across items called "charms", they do nothing but consume inventory space. Bank them ASAP.
-The point of no return is on day 5, where there is a door propped open with substance around it.
-Most spells are pretty useless. Notable ones to use are ones that heal you, or the one you learn at level 20.
-on day 6, whatever gun and armor you choose to custom name, will carry over to new game plus. Everything else in your inventory will disappear, so make sure you bank everything else that's important at that point.
The following is the ideal use of your tools/mods to use, as well as detailing which guns/armour are relevant. I've hidden it in spoilers in case you don't want locations, or boss names spoiled.
>!Weapon: Use the MP5PDW from museum and do the following: 1. Add slots to the gun until it has 4 open slots total (4/6 maximum slots possible) 2. Tool the burst mod from a shotgun (either the M870 from Chinatown Sewers or the M500 from Museum 4th floor) onto the machine gun to get rid of the random target mod 3. Tool on double command from the M8000 (T-rex boss from museum) or from the M9-3 (Museum 3rd floor) 4. Tool on quickdraw from the PPK (Warehouse, chest outside) 5. Tool on 2x rate of fire or 3x rate of fire from any gun that has it (I prefer 3x) 6. Prioritize getting 80-100 range before adding attack. I like to reach 150-200 range at some point, as range will increase the effectiveness of your burst mod. Armor: Use the N-suit found in Museum. This has the highest number of slots available during your first playthrough. Do the following: 1. Add slots to the armor until it has 5 slots available 2. Tool on auto potion (CM Vest 1 and 2; found in NYPD locker room and conference rooms respectfully) 3. Tool on item capacity + 1 (Sv vest 1, found in central park forest on day 2) 4. Tool on resist poison (B Vest 1, found in the 1st floor of the hospital) 5. Tool on resist stiffness (B Protector found in the subway) 6. Tool on HP Plus (Cr Protector found in sewers)
After all of that, prioritize all your tool uses for guns that add range/attack onto your gun. Due to how limited tools are, I'd recommend only tooling off guns that give a total of 2 stats of any combination of range/power. Armor isn't as important. Note that you won't have enough permits to add slots to both your gun and your armour on your first run, unless you abuse the bug that allows you to infinitely loot mod permits in the hospital on day 4 (you just keep mashing the confirm button to keep looting).!<
The reason we use the machine gun, is because it has the fastest fire rate possible. Range can be fixed with adding stats, but fire rate can't be modified.
You don't really need any other mods not listed here. The other status effect mods are pretty unreliable and inconsistent. Some of them even decrease your damage against certain enemies, so I would stay away from those.
The following spoiler details the key items to find in the "secret" content you won't know about yet.
>!Here are the key items in Chrysler to look out for:
B Jacket 2 (floors 21-30, resist darkness) Cm Suit 1 (floors 31-40, auto-cures to remove status) Sv Armor 1 (floors 41-50, Item Capacity +4) Sp Armor 2 (floors 51-60, Atk Pow +) Cm Armor 2 (floors 61-70, PE Light mod) Cr Armor 2 (floors 61-70, Max HP+) *** Endgame armor with 7/10 slots
Type64 (floors 21-30, crit up) G20 (floors 41-50, counter attack) or M712 (floors 51-60, counter attack) MP5SD6 (4/7 slots, floors 51-60, best non-junk machine gun weapon) M96R (floors 61-70, triple command)
The mechanic guide from gamefaqs says differently, but from my experience you gain access to the toolbox (infinite tools) after clearing floor 50 of the chrysler building (10 trading cards used) and supertool box (14 trading cards used) after clearing floor 70. (This is if you loot every single trading card and use them). Once you gain access to the supertool box, you'll be able to easily transition your current weapon and armour to the MP5SD6 weapon and CR Armor 2 found in Chrysler. The reason we use the machine gun, is because it has the fastest fire rate possible. Range can be fixed with adding stats, but fire rate can't be modified.
If you decide to farm 300 junk (absolutely not necessary), then go for the P90. Just follow the same steps for tooling as listed above. The P90 is better than the MP5SD6 found in Chrysler.!<