Taking drugs was a focal point of my 20s.
Party drugs for the most part, predominantly MDMA, which I took practically every weekend for many years.
As soon as I hit 30, I lost interest in the party lifestyle, and party drugs.
I've used alcohol as a social lubricant since I was 21, and still to this day.
But now at 40, I drink much less frequently, and I'm considering cutting it out altogether. It really interferes with my exercise schedule, and exercise is infinitely more rewarding for me.
Opiates are for relief of serious pain. Aside from that, they do nothing for me.
Nicotine I crave when I drink alcohol, otherwise I don't touch it.
THC. I can't even put into words how much I hate it. I mean, I have no problem whatsoever with other people using it or being around it. But there is no substance less suited to me. It gives me an instant crushing mental and personality disorder. I detest it.
Psychedelics. I've used many times and got benefits from them. Even the scary experiences I view as being ultimately positive. But I have no interest in using them ever again.
Benzos, anti-depressants, and things of that nature, I have never tried and never will.