Err in English it definitely is. Maybe not in your context but if your speaking in English context yes. It would be quite offensive to call a lady Handsome.

handsome ˈhans(ə)m/ adjective adjective: handsome; comparative adjective: handsomer; superlative adjective: handsomest

1.
(of a man) good-looking.
synonyms:   good-looking, nice-looking, attractive, personable, striking, stunning, fine, well-proportioned, well-formed; More
informalhunky, dishy, hot, gorgeous, drop-dead gorgeous, tasty, fanciable, knockout;
informalfit;
informalcute;
informalspunky;
raresightly
"a handsome, dark-haired young man"
antonyms:   ugly
    (of a woman) striking and imposing rather than conventionally pretty.
    synonyms:   striking, imposing, prepossessing, elegant, stately, dignified, statuesque, good-looking, nice-looking, attractive, personable
    "a handsome woman of 30"
    antonyms:   plain
    (of a thing) well made, imposing, and of obvious quality.
    "handsome cookery books"
2.
(of a number, sum of money, or margin) substantial.
"he was elected by a handsome majority"
synonyms:   substantial, considerable, sizeable, large, big, ample, abundant, bumper, plentiful;