Err in English it definitely is. Maybe not in your context but if your speaking in English context yes. It would be quite offensive to call a lady Handsome.
adjective: handsome; comparative adjective: handsomer; superlative adjective: handsomest
(of a man) good-looking.
synonyms: good-looking, nice-looking, attractive, personable, striking, stunning, fine, well-proportioned, well-formed; More
informalhunky, dishy, hot, gorgeous, drop-dead gorgeous, tasty, fanciable, knockout;
"a handsome, dark-haired young man"
(of a woman) striking and imposing rather than conventionally pretty.
synonyms: striking, imposing, prepossessing, elegant, stately, dignified, statuesque, good-looking, nice-looking, attractive, personable
"a handsome woman of 30"
(of a thing) well made, imposing, and of obvious quality.
"handsome cookery books"
(of a number, sum of money, or margin) substantial.
"he was elected by a handsome majority"
synonyms: substantial, considerable, sizeable, large, big, ample, abundant, bumper, plentiful;