Queen Elizabeth meeting Manchester terror victim

Err in English it definitely is. Maybe not in your context but if your speaking in English context yes. It would be quite offensive to call a lady Handsome.

handsome ˈhans(ə)m/ adjective adjective: handsome; comparative adjective: handsomer; superlative adjective: handsomest

(of a man) good-looking.
synonyms:   good-looking, nice-looking, attractive, personable, striking, stunning, fine, well-proportioned, well-formed; More
informalhunky, dishy, hot, gorgeous, drop-dead gorgeous, tasty, fanciable, knockout;
"a handsome, dark-haired young man"
antonyms:   ugly
    (of a woman) striking and imposing rather than conventionally pretty.
    synonyms:   striking, imposing, prepossessing, elegant, stately, dignified, statuesque, good-looking, nice-looking, attractive, personable
    "a handsome woman of 30"
    antonyms:   plain
    (of a thing) well made, imposing, and of obvious quality.
    "handsome cookery books"
(of a number, sum of money, or margin) substantial.
"he was elected by a handsome majority"
synonyms:   substantial, considerable, sizeable, large, big, ample, abundant, bumper, plentiful;
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