Max Temkin (one of the co-founders of Cards Against Humanity) on the business impact a poor choice of words (from one of the Penny Arcade guys) can have:

I wasn’t at that panel, but word reached me that afternoon and I knew shortly after that a good amount of the work we had done for PAX had been washed away. After the show, nobody would remember the cube that I spent months designing or the cards and fortune cookies that we gave out, they would only remember that quote. I believe my exact words were, “Mike just fucked us.”

Damien Schubert from Bioware chimed in with the only way to deal with this situation:

Third, game culture is in desperate need of dedouchification, but you don’t change public opinion by preaching to the converted. You don’t need to sell girls on Geek Girl Con that the concept of ‘fake geek girls’ is broken and insulting. You don’t need to sell GaymerX attendees that trans gamers need understanding. You need to bring this understanding to the gaming audience at large. In America, that audience’s largest gathering is PAX.

Bank robbers rob banks because that’s where the money is. If you are an activist who wants to enact social change in the gaming community, you need to go where the gamers are. You can set up talks, you can challenge the PAX guys to give you a booth like they did AbleGamers, you can organize protests, you can set up debates, you can wear coordinated T-Shirts designed to shame and expose douchebaggery in all its forms. Or, you can run away and hope somehow that the problem fixes itself. Turning the largest american consumer-oriented gaming show into even more of a sausage fest makes it pretty unlikely that that’s going to happen.

[The first link, to Max Temkin's blog, has links to the full story of the horrid dickwolves debacle.]