Why do some people prefer stimulants and other depressants?

Meth is the only stimulant that makes me feel euphoric. High grade fish scale coke and regular amphetamine (adderall) just dont really do anything for me. Meth is euphoric but I really wouldnt want to take it very often. It makes me anxious the following day and unable to sleep or eat. I only take it when I need an adderall boost in very rare occasions (I dont have a script anymore), and occasionally Ill take meth instead of rolling 2-3 days in a row since it provides a similar body high and energy as MDMA. Other than that I wouldnt want to take it because of the side effects. Opiates dont make me feel as euphoric as meth or mdma, but what they do is allow me to get full restful nights of sleep, eat 3 meals a day, almost alleviates all of my physical pain from IBS and my back injury, and completely alleviate severe depression+anxiety and PTSD which allow me to live a pretty normal life other than blowing my money on opiates. I do take relatively small doses of opiates and I regulate my usage on my own and for the past few years I have not had any issues holding my job and staying functional. Sadly enough, I'm easily more functional on a small dose of opiates than sober.

/r/Drugs Thread