I’ve heard convincing arguments that this anti-transhumanism could be viewed as ableism, as often the negative effects of transhumanism depicted are often instances where the modification is doing the work of compensating for eliminating a disability.

The biggest example I’ve seen is the treatment of Airiam, whose life-saving augmentations are ultimately the cause of much death and destruction in season 2. One could interpret this as a subtextual message that it’s better to leave one’s self in a “natural” state (in this case, death), than being dangerously modified.

Furthermore, the plotline of Bashir’s genetic status is equally troubling, since the subtext there seems to be that any attempt to improve a disabled child’s quality of life through genetic augmentation will always end up in Khan-like abominations. Therefore, it’s best to just keep the disabled in their “natural”, non-threatening state.