Yes, a mirage sleight of hand nuke is second only to Saryn in room clearing capability. Noting that, the marked for death (Helminth) nukes are a meta in formation and currently undecided by general consensus. With nukes like Saryn and Mirage, you just don't need defense mission frames. The second most note worthy is Wukong prime, he can utterly cheese spy missions and is great for speed runs. I put Ivara next because, even with her Infiltrate augment, you have to slowly walk past lasers. But she has many other valuable niche uses such as perfect animal captures, afk neo axi relic farming, nightwave challenges, riven challenges, and even soloing eidolons. Another thing to focus on is Mesa because she is next in line to get vaulted, so stock piling her can prove to be quite profitable. The rest are much desired MR fodder. All of which, you can use to get plat for frames that are currently vaulted.