I'm running a SuperFlex Guillotine League:
1QB, 1RB, 2WR, 1TE, 1Flex, 1SuperFlex, D, K
QB scoring is adjusted to 0.04/passyd and -4/INT. This keeps top QBs as your high performers, but drops mid-tier QBs down a bit to where it becomes viable for one of the other positions to be started in the SuperFlex spot.
RB/WR is PPR scoring with TEs getting 1.5/PPR. Top TEs shoot up in value, but mid-tier TEs become usable as Flex.
Defensive scoring gets "You deserve better defensive scoring"
FG = 3pts + 0.1 per yard over 30
Missed FG 0-30= -3
Missed FG 31-39 = -2
Missed GF 40-49 = -1
XP = 1 point
Missed XP = -1 point