What title from film/TV, theatre, literature, etc. would be best reused for a totally different idea or story?

Open with cool alt-rock song over shots of a gorgeous, immaculately manicured college campus. Shy awkward Alice waves goodbye to her dorky, Midwestern parents as they drive away in their station wagon. It's her first day, and she's nervous and excited. She stands marveling at the beauty of the old ivy covered buildings, taking it all in. But she's a total klutz, and accidentally spins into Mark (strong, classically handsome upperclassman) and their eyes meet as he helps her pick up his books. After breifly exchanging names she is inexpliably swept away by a sudden hoard of passing students, cutting their moment short. On the way to class, she stops in to the restroom to check her hair in the mirror and is startled by bad-boy Andrew, who is getting stoned with two girls in one of the stalls. He drops some witty one-liner as he breezes past her. Alice is repulsed, albeit intrigued. But oh no! She's late for her first class! Of course she walks in in front of a full lecture hall, and the Professor (Diane, mid-40s) makes some comment about Alice's tardiness, and the other students chuckle, and the whole thing is just dreadfully embarressing (but don't worry because when Alice is having her crisis during the 2/3 section of the movie, Diane will provide some concise, but incredibly insightful advice that applies perfectly to Alice's situation, even though Diane hasn't been around for any of it, and by the end they will somehow have this tear-jerkingly beautiful mother/daughter relationship). As Alice finds a seat, we key in on Jack, a nerdy, sensitive loner, whose boyish good looks are cleaverly disguised by the film makers with a pair of glasses. In a panic, Alice realizes she forgot to bring a pencil, but Jack offers her one of his from the row behind. She says a quick thanksand gets to work, barely registering him. This sets up the initial (supposed) thesis of the film: Mark (good-guy), Andrew (bad-boy) and Jack (the ugly duckling). The Good, The Bad & The Ugly. Fast forward through scenes of Alice flirting with Mark while he's doing sporty stuff; Alice warming up to Andrew while he's doing cool guy stuff; and Alice sharing nice little non-romantic moments with Jack. Also at this point she has become best friends with her Asian goth roommate Chrissy, and Chrissy's sassy gay best friend from high school, Devon. Alice confides that she's beginning to have feelings for both Mark AND Andrew, and doesn't know what to do. Many funny things happen in this part - you just have to trust me. Our epic saga comes to it's conclusion at the end of the year keg party. Based on the combined advice from Chrissy, Devon and Diane, Alice has decided to put her heart on her sleeve, tell both Mark and Andrew how she feels, and see what happens. However, before she can, Mark does something totally douchey that illustrates that he's been a dick the whole time (we kinda saw that coming), changing the way Alice sees him. Then she goes to Andrew, who in what is potentially a romantic moment in her eyes, confesses that he has realized he's gay (ok this one's a little out of left field) and in the following conversation Alice realizes he's not the hard-hearted

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