What's the best way to ruin a perfectly good bout of depression?

True, but there's a lot of information out there if you're willing to look. If you're just willy nilly dosing, then you likely aren't going for the medicinal benefits. The age old idea of starting small and increasing if benefits aren't recognized is still a valid method that even doctors would likely recommend. Unlike a lot of pharmaceuticals, psychedelics are effective the day you take them; there is no week plus acclimation. If you dose too small and nothing happens, increase your dose a little more the next time you try it. For daily medicinal use, taking enough to hallucinate is too much. erowid.org is a good source of information for those that may be interested.

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