Every single time I've been put on a psychoactive drug by the medical establishment to treat my slew of mental issues it's either a.) helped for a while then stopped, or b.) made things worse.
On one, I sleep-walked a lot more. Once, to Walmart. Naked. And I sleep-collected-power-tools-and-put-them-in-bed-with-me.
The last drug turned my delusions into full blown audio-visual / tactile hallucinations. I had just seen Insidious 1 and 2 before being put on it, and... it wasn't exactly "the man with fire on his face" or "the bride in black" ... but those are close enough descriptions to get across the idea. They were much, much scarier. And they looked / sounded / felt real. It got so bad that I even named them, and started getting feelings like I should do some religion--any religion--if it'd just make it stop. (I'm an agnostic... The Bob that can be described is not the true Bob... And 'God' is a handy catch-all metaphor for 'That Which We Do Not Yet Understand.') I eventually got off the medication when I got hold of my doctor. Luckily, I didn't get the other side effect of the drug which was "your skin all falls off."
The 12~ years of therapy was all bullshit too. DBT, CBT, a bit of ACT... all kinds of shit. Fucking hypnosis ... ugh.
"Professional help" made things much worse for me when I "sought it."
And people don't understand how bad the medical industry is. Obamacare covers NOTHING. I cannot get any diagnostics done--they only treat. For someone with next to no documentation (abusive parents decided instead of trying to get their neurologically depressed / autistic / ADD / epileptic / ??? kid help, they'd abuse it and give it PTSD and make shit worse) this essentially means that I'm fucked.
Luckily, I found something that helps. Cannabis pretty much is the only drug that has consistently done a job of helping me cope with life day to day. I realize it just masks the issues, but fuck it--without it, I'd have killed myself by now. It makes life bearable. It doesn't change the fact of my physiological / neurological instabilities... and it doesn't erase the memories of all of the horrible shit I've lived with... it just helps me to not care for a while.
When I use it, things change from a bleak and endless gauntlet of never-ending pointless misery and almost seem like they might be somewhat enjoyable.
I've taken extended breaks from it to ensure that it's not just 'withdrawal' or dependence on it or whatever. It's not.
TL;DR Psychiatric drugs and therapy didn't help, made shit worse. Cannabis helps. It's a band-aid I'm slapping on a sucking chest wound, but it's better than the alternative which is nothing.
EDIT: Holy shit. Sorry for the rant. There is no one for me to talk to about my problems. By which I mean, no one with any authority to change anything / do anything about it. I have plenty of people who will LISTEN, just... no one who has any answers or authority to help.