You have initiators and chaining skills. You start with initiators, and chain into chaining skills. Initiators in order of importance (if they're all off CD, use them in this order, and once you're done with a chain start at the beginning of the list again if possible):
Chain (chain in this order, every time, after using an initiator; if you can't do one because it's on cooldown, skip to the next thing on the list):
Sometimes, you may want to cut the chain short by going 1->4, or even shorter 2->4, if you're going to need to dodge or the boss is turning around (since you want to offload all your good stuff on its back).
Mana regen:
Gap closing (in no particular order):
Other skills:
Other general considerations: * Use nostrums, ex "Nostrum of Energy V." These can be purchased from any regular merchants. They decrease cooldowns and therefore decrease the amount of time you're standing there doing nothing, or just filler abilities. * If you have nothing else to do, use your Combo Attacks. This should not ever happen, provided that you are using nostrums. You should not ever be standing there doing nothing. Combo Attacks do very little, but at least it's something, and it helps with mana.