Which chambers give you the most trouble?

Personally, I'd go with Diluc - Xingqiu - Diona - Traveller (or Keqing, if Traveller is too low levelled/gets killed to quickly)

Diluc and Xingqiu have great synergy with vape, Diona for healing and shield + cryo, and traveller for the anemo/swirl.

Chamber 1: get rid of the hilichurl shooters first. They can lead to annoying reactions. The slimes are slow so you can dodge them easily. If possible, use Traveller to swirl the pyro slime with the cryo slime to break it's shield, then use Diluc to finish them off. Again, Xingqiu's burst is great with Diluc, so make sure to put as much energy recharge on Xingqiu as possible with your artifacts.

Chamber 2: get rid of the potioneers first, you DO NOT want to be frozen/overloaded. After you've taken out at least the cryo and electro ones, you can get rid of the rest.

Chamber 3: I personally like to focus on mitachurl first, then the ruin guard. Remember that Ruin Guards have resistence to physical, so use mostly skills/bursts to take them down. (If you use Keqing, then use superconduct).