Agree with most of what’s said. 3 or 4 encounters a day is a good idea, so I think, but I’d only make half of those hostile encounters. Give them a shrine to discover or interesting ruins here and there.

For combat encounters, I’d make sure to introduce them to the representative creatures of the Trickster Gods before they hit Omu so they can better conceptualize the creatures.

Definitely don’t try to use everything in the book, there’s too many threads. Probably have the threads there, but just don’t even mention them unless asked. Kwayothe’s fiend consorts and fire worship? Trivial and unimportant, unless suddenly something get’s the player’s interest. Paladin casts Divine Sense in Goldenthrone and sees two fiends? Suddenly interested? Now it’s a thread worth picking up. But there are just so many.

I also recommend making the Dino races and Executioner’s Run something they hear about early on. Races are good fun.