Yes you can! I did!
Here is mine:
PCPartPicker part list / Price breakdown by merchant
| Type | Item | Price |
|---|---|---|
| CPU | AMD Athlon X4 760K 3.8GHz Quad-Core Processor | $71.98 @ Newegg |
| Motherboard | Gigabyte GA-F2A88XM-D3H Micro ATX FM2+ Motherboard | $63.99 @ Mwave |
| Memory | G.Skill Sniper Series 8GB (2 x 4GB) DDR3-2133 Memory | $59.99 @ Newegg |
| Storage | Western Digital Caviar Blue 1TB 3.5" 7200RPM Internal Hard Drive | $44.99 @ Best Buy |
| Video Card | MSI Radeon R9 270 2GB TWIN FROZR Video Card | $169.99 @ Amazon |
| Case | Corsair 300R ATX Mid Tower Case | $69.99 @ Amazon |
| Power Supply | Corsair CX 500W 80+ Bronze Certified Semi-Modular ATX Power Supply | $59.99 @ Amazon |
| Optical Drive | Asus DRW-24F1ST DVD/CD Writer | $17.69 @ OutletPC |
| Wireless Network Adapter | TP-Link TL-WDN4800 802.11a/b/g/n PCI-Express x1 Wi-Fi Adapter | $34.80 @ Amazon |
| Prices include shipping, taxes, rebates, and discounts | ||
| Total | $593.41 | |
| Generated by PCPartPicker 2015-04-05 17:13 EDT-0400 |
However, I would recommend a bigger, more option-filled Mobo because I can't get another video card if I ever choose to crossfire because my mobo won't fit them both along with my TP Link. Bad decision on my part.