How to disable the automatic color selection of Windows
Since recent updates of both Windows 10 and Chrome (73.0.3683.75), many people see their screens flickering until they close Chrome. To stop this from happening, you'll have to disable the automatic slideshow of desktop backgrounds in Windows or the automatic selection of a color for windows and the task bar. Here's how. If the steps above do not help, try this: How to disable the Windows Slideshow
At the moment, it is not known why these two settings cause your screen to flicker in Chrome.