Persona is a modern anime with school, slice of life and a rowdy badass group of teenage super heroes (akin to strike the blood, trails of cold steel or my hero academia)

Shin megami tensei is an old school Shonen anime with adult themes (yuyuhakusho, dragon ball z or inuyasha)

Persona focuses on character, psychology, mental health, trauma and utilizes waifu, sex appeal and player empowerment and dick sucking

Smt focuses on religion, mythos, philosophy and utilizes pseudo intellectualism, player choice, immersion and tact

Persona is rich, kind of a dumbass but hard working, is extroverted, likes to party and is a total Chad

Smt is middle class, well read and intelligent, antisocial/introverted, enjoys playing chess but is a total virgin