Yes and no. Let's say you have four fantastic WR's and a QB with great throwing mechanics. While ideal for the Air Raid or Run 'n' Shoot before, you wouldn't just come in one day, and run one of those systems that you have no experience with. This is where the "stealing" part of coaching comes in. Visit that system and take a scheme or two out that fits into what you are already good at.

My favorite example is an option team who can't find a tough or athletic QB to run the ball; run double dives off the core option plays. Instead of FB dive and QB keep, run FB dive, then tailback dive off tackle. If you need an outside/pitch threat, have a quick WR screen set up. Another way to look at it is if you're a base 21 personnel (2WR's, 1TE, 1RB) and you base out of an I-formation and use power/zone schemes. You now find yourself with 3-4 great WR's and a great throwing QB. Do utilize them, do everything the same but take out your fullback and use a third receiver. Don't move or change anything else. Rotate that 4th receiver in as a sub to give the other receivers a rest, and you could relay plays into the QB that way too. Yes, adapt to your players. No, don't run a whole new system.