I made a copy of my registry settings before making a driver update. Restoring these entries seemed to help my situation when vkEnumerateInstanceLayerProperties would return nothing.

[HKEY_LOCAL_MACHINE\SOFTWARE\Khronos\Vulkan\ExplicitLayers] "C:\VulkanSDK\1.0.21.1\Bin\VkLayer_api_dump.json"=dword:00000000 "C:\VulkanSDK\1.0.21.1\Bin\VkLayer_core_validation.json"=dword:00000000 "C:\VulkanSDK\1.0.21.1\Bin\VkLayer_image.json"=dword:00000000 "C:\VulkanSDK\1.0.21.1\Bin\VkLayer_object_tracker.json"=dword:00000000 "C:\VulkanSDK\1.0.21.1\Bin\VkLayer_parameter_validation.json"=dword:00000000 "C:\VulkanSDK\1.0.21.1\Bin\VkLayer_screenshot.json"=dword:00000000 "C:\VulkanSDK\1.0.21.1\Bin\VkLayer_swapchain.json"=dword:00000000 "C:\VulkanSDK\1.0.21.1\Bin\VkLayer_threading.json"=dword:00000000 "C:\VulkanSDK\1.0.21.1\Bin\VkLayer_unique_objects.json"=dword:00000000 "C:\VulkanSDK\1.0.21.1\Bin\VkLayer_vktrace_layer.json"=dword:00000000