You always have a chance but I wouldn't throw huge money on it. It's not like march madness where you could win by flipping a coin, but it's not 100% skill based. You could just follow projections and play like that. Draft what the autodraft tells you to draft, go on player comparison sites to see who is favored week to week. Honestly you could win the whole thing just by checking your roster once and week and being lucky.

In my league this year, a girl that was playing for the first time almost won the whole thing based on luck. Basically all her top draft picks happened to be healthy, and she happened to have autodrafted a bunch of the people that unexpectedly blew up.

Bottom line is you don't actually need to know everything about the NFL to play. Really most of the important stats are laid out for you, so if you understand that a bigger number is better than a smaller one you don't need to know the other details. Lots of people think themselves into losses by over analyzing things. You sit your starting QB because he usually doesn't play well in the cold and your backup QB is playing against the worst defense in the league. You make your switch and your top QB gets his usual 28 pts. while the backup only gets you 8. You can never know.

Not to suggest you live off of the projections. It's very rare for them to be exactly right, and sometimes they're drastically wrong. But if you don't want to sit there figuring out which direction the wind is blowing that week and how well your running back historically does against the opposing defensive coordinators line, that's the way to go. The most important and easy thing you can do to help you win is keep track of the injury reports and not play someone who ends up not playing because they're hurt.