The difference of 33k is substantial, but for $4k it better be a much better vehicle cosmetically and otherwise. Ask yourself, how many miles do you drive in a year? If I drive 5k miles a year I might be willing to spend a couple grand more for 33k less miles that would essentially extend the life of the vehicle many years. Remember that yes a Lexus is more reliable from a powertrain standpoint (engine/tranny), but suspension, brakes, tires, and other "maintenance items" are still giong to need replacement depending on mileage.

To give you some perspective I buy used Toyota/Lexus vehicles around 98k miles and drive them until about 200k+ before selling them. My last Lexus purchased at 98k needed new struts (suspension) by that point, but everyone else was great. I normally hit that 200k mark in about 5 years, but if I was planning to keep one longer I'd definitely aim for less mileage.