My husband sent me the link to you, which we both read and had the major feels. We have been struggling with something very similar for 6 years now. I had the whole thing your wife had: remove gallbladder, remove appendix. Liver cysts, endometriosis, ulcer, it has gone on and on and on. Here's what I can share with you: you need a comprehensive surgical facility. I recommend the Mayo Clinic. I got very good results there, the Cleveland Clinic wasn't as comprehensive or responsive. In one facility they will have her see as many specialists as it takes: OB-GYN (which needs to be checked, the symptoms you describe can all be related to scarring/tissue/endometrial issues) pain, gastro, everything. She may also need help with what has obviously become a serious nutritional issue. If you have concerns about insurance covering something like this, you can get pre-approval. They also have charity you can apply for at Mayo's. I did and was awarded enough to cover a good portion of my 10 day stay although YMMV. They found many things a standard hospital simply couldn't. For example, it turns out I am resistant to many forms of pain medication due to a rare genetic malfunction. They learned this doing a proprietary DNA analysis. This, after 15 years of doctors saying "I can't believe you're still awake! I gave you enough (whatever) to kill a horse and it had no effect at all?" The other thing going to Mayo's did for me was eliminate the runaround. After seeing my intake doctor (in this case a psychiatrist because nobody could figure out why I couldn't feel 10 mg of morphine) they made ALL of the appointments at other specialties for me. They just plopped me in a wheelchair and took me where I needed to be. It was the first time a doctor ever started the conversation with the idea that my case was rare, that's why I needed to be seen there. They were excited to find the weird thing others missed. If you can even think about her going someplace like the Mayo Clinic, I hope it works out. As a side note, I have heard pot helps to regain appetite with pain. Since it's illegal where I live I would certainly never admit it worked for me, especially cooked into food. Especially, especially not that it helped the most on days when the pain was not acute but rather a constant, lower level pain that needed easing so I could eat/drink but you need to start very slowly because if she's not used to pot you don't want her to get high, just hungry. Nope. I'd never say that. Good luck to you both.