If you want to use weaponry, Mirage can deal ridiculous damage through the use of her first and fourth abilities. She's so good with the synoid simulor she actually ruins the fun for a lot of other players.

Chroma is able to quintuple his damage output and tank the gods themselves. He's really interesting to play and has an incredibly high potential.

The categorically strongest weapon frame is banshee. Her second ability increases your weapon's damage by over 1000% if you can aim at weakspots.

The Strongest damage dealer with abilities is Equinox. Her fourth ability, maim, scales with the health of enemies you kill. The higher the enemy level, the more health they have, the more maim gets stacked when they die, and the deadlier the burst is.

The three other frames that have scaling abilities are chroma, trinity, and frost. Trinity's energy vampire deals a percentage of the target's health, as does chroma's toxic elemental ward. Frost's third ability, snowglobe, ragdolls enemies caught in the initial cast for a percentage of their health.

The strongest flat damage dealer is nova. Molecular prime and a fully-charged antimatter drop deal 400k damage to a group of enemies.