It is my opinion that Buddhism can provide a framework or create the conditions where the type of realization that you are referring to can occur.

There are 3 components of our existence that must be 'harmonized' for this realization of the 'ultimate' reality to occur.

We have a physical brain, a physical body and we live in a physical world. Emphasizing and focusing on just one those components will not lead to the 'experience'. Rather a balance must be achieved between all three. A healthy brain, a healthy body and the right external conditions. Mediation only deals with our brain.

Then Anathapindika the householder, surrounded by about 500 lay followers, went to the Blessed One and, on arrival, having bowed down to him, sat to one side. As he was sitting there the Blessed One said to him, "Householder, you have provided the community of monks with robes, alms food, lodgings, & medicinal requisites for the sick, but you shouldn't rest content with the thought, 'We have provided the community of monks with robes, alms food, lodgings, & medicinal requisites for the sick.' So you should train yourself,

'Let's periodically enter & remain in seclusion & rapture.' That's how you should train yourself."

During our daily life, unless we are a monastic, we should do what we need to cultivate a healthy body...exercise, diet, lifestyle. We should also be creating a healthy relationship with our external world, with a state of mind that embraces selflessness, kindness and compassion.

Anathapindika in his role as a householder was able to provide a place for the Buddha to live and he had the means to provide the community of monks with robes, alms food, lodgings, & medicinal requisites for the sick.

Having fulfilled his responsibilities as a householder and selflessly supported the monastic community the Buddha suggested Anathapindika...'Let's periodically enter & remain in seclusion & rapture.'

This 'rapture' I would associate with the perception of ultimate reality you are referring to.