I didn't read all replies so I hope I'm not repeating someone. There is more to your question though than play-ability, which it seems is all your asking about and most of your replies are about. I would like to say that until you are educated on what and how a proper set up is done there is no substitute for a good tech and proper setup. It will make a huge difference play-ability. That being there will still be differences in how a LP style feels compared to a Strat style guitar. Most of that is in the neck. Things such as fingerboard radius and neck width. The more you play on different guitars you will probably develop a preference to a particular neck width and radius but then as you skill level increases you should be able to adapt quickly and appreciate each for what it brings to the table. But other things to look for as to what makes a quality guitar is just as important. Cheap guitars like epis and squires use cheap wood and components. The guitars that are even cheaper use even cheaper wood and components. There's a difference even in how the wood is processed. A neck that is quarter sawed or half sawed ( decides which way the grain of the wood lays) will make a difference in whether your neck stays true or bows or worst case starts to twist. How is the body made ? Is it a one piece or three piece or is it saw duct glued together? This makes a difference both tonaly and lifespan. Most important I think is how was the wood cured. Was it kiln dried? was it kiln dried properly? So a quality guitar is build with these things in mind. Quality wood that is properly dried and cut. Quality paint or nitro instead of spay cans from the Chinese version of Home Depot. Then the other components. Like what type of metal is you bridge and tuners made from. Is it quality steel or pot metal thats going to eventually warp and the shiny metallic flake peel off. Are the pots and caps good or are they bargain basement stuff that's going to give you problems in the years ahead. The more expensive guitar companies use better quality materials which cost more. We hope anyways. They use better craftsmen to build that guitar which costs more also. But , hopefully,, when you pay that premium you have an instrument that will last you for years. Also be an investment as it will hold it's resale better. A guitar that was built by Wang Chin and his 14 cousins out of green wood with the cheapest components will cost you less in the long run but there's a good chance that within a year or two your going to end up tossing it. Look up on you tube, Paul Reed Smith talking about building a perfect guitar.